TAIWAN—New research published in the Chemical and Pharmaceutical Bulletin, found an eucalyptol microemulsion system may be a promising tool for the percutaneous delivery of curcumin, which is used for treating various skin diseases like scleroderma, psoriasis, and skin cancer (2011;59(2):172-8). The solubility of curcumin in various oils, surfactants, and cosurfactants was studied in order to find the optimal components for a transdermal delivery vehicle. Microemulsion systems composed of eucalyptol, polysorbate 80, ethanol,and water were developed as transdermal delivery vehicles for curcumin. Effects of the microemulsion composition on transdermal curcumin delivery were studied using Franz diffusion cells. The transdermal curcumin flux, permeability coefficient and enhancement ratio were analyzed to evaluate the effects of eucalyptol/water ratios in the microemulsions. Pseudo-ternary phase diagrams of the eucalyptol microemulsions with various surfactant/cosurfactant ratios (1 : 1-1 : 3) were constructed to investigate their phase behaviors. Conductivity, interfacial tension, size and viscosity data of the microemulsions were used to characterize the physicochemical properties of transdermal vehicles. The influence of the microemulsions on skin histology and on the delivery route was analyzed using hematoxylin/eosin staining and confocal laser scanning microscopy.
In conclusion, microemulsions were successfully developed for transdermal curcumin delivery after screening various components and adjusting the oil/water ratios .The curcumin permeation rate of the microemulsion developed was 15.7-fold higher than that of the control (eucalyptol only).