MILAN, Italy—Italian researchers reported, in tests in volunteers affected by hair cycle disturbance, a combination of conjugated linoleic acid (CLA) glutathione and sodium DNA showed efficacy and tolerability at a comparable or even superior level to minoxidil (Cosmetics & Toiletries; October 2007:71). The best results were obtained in terms of hair traction resistance and fast anti-loss efficacy, and the active blend proved to be well-tolerated by the volunteers who found it acceptable.
The study describes a molecule created by fusing CLA with glutathione, each of which has intrinsic biologic activity. The peculiarity of CLA glutathione lies in its chemical structure based on the lipophilic linoleic acid and the hydrophilic glutathione tripeptide. The resulting molecule is shown to be capable of bypassing the hurdle of skin transport (because formulation strategies designed to establish the simultaneous presence of potentially active substances in a formula are frequently hindered by the “resistant" activity of the skin) and to be efficacious in optimizing the co-presence of different actives. In this case, CLA glutathione was combined with sodium DNA for a new approach to the treatment of premature hair loss and the combination formula proved to be a possible representative for a new approach to treatment in products aimed at premature hair loss.