SCARSDALE, N.Y.—A double blinded, randomized, controlled clinical usage study reported—compared to the control—statistically significant improvements in the appearance of photoaged skin after 12 weeks of topical application of a novel, multi-ingredient, polyphenol, high-antioxidant skin care system (facial wash, day lotion, night crème and eye serum), containing Coffea Arabica, and concentrated fruit and vegetable extracts (J Drugs Dermatol. 2010 Dec;9(12):1480-7).
A total of 40 Caucasian female participants were randomly assigned to apply the test regimen or control regimen for 12 weeks. One group washed with the test antioxidant facial wash twice daily, applied the test antioxidant day lotion each morning, and the test antioxidant night creme and eye serum each evening. The second group washed with a control facial wash twice daily and applied a control moisturizer each morning and evening. Clinical evaluations for efficacy were made by a board-certified dermatologist at baseline, and after six and 12 weeks of product use. Efficacy was also measured by subjects' self-assessments and via photography and instrumentation.
Overall, the results of the study showed the test regimen produced statistically significant improvements in the appearance of photodamaged skin. Most impressive was the significantly greater improvements produced by the test regimen over the control for nearly every grading parameter. The results demonstrate this high total ORAC-scoring antioxidant skin care system was well tolerated, with no adverse events reported by the participants during the course of the study. It improved—significantly greater than the control regimen—the appearance of wrinkles, firmness, hyperpigmentation, blotchy redness, tactile roughness and clarity in photodamaged skin. Post-baseline clinical grading scores, silicone replica parameters, cutometer and corneometer scores were statistically compared to baseline.