Nanoparticle Encapsulation Aids Vitamin A Delivery

MUMBAI, India—Using a solid lipid nanoparticle (SLN) carrier system for topical application of vitamin A palmitate increased bioavailability of the compound and improved skin hydration (AAPS PharmSciTech. 2006;7(4):91). Researchers from SNDT Women’s University prepared topical gels enriched with vitamin A SLN using polymeric gels of carbopol, pemulen, lutrol and xanthan gum. In vitro release profile from the nanoparticular dispersion showed prolonged release up to 24 hours, which researchers attributed to embedment of the compound in the solid lipid core. In vitro penetration studies showed the SLN system doubled the vitamin A palmitate concentration in the skin, compared with conventional gel. Also, in vivo skin hydration studies in albino rats showed an increase in the thickness of the stratum corneum with improved skin hydration, with no irritation.

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