Gallic Acid Exerts Antimelanogenic Activity

10/25/2007

BUSAN, Korea—Investigators from the Department of Cosmetology, Pusan Women’s College, looked at the melanogenesis-inhibitor y action of gallic acid (GA) in a quest to identify novel skin-whitening agents (Biol Pharm Bull. 2007 Jun;30(6):1052-5). The study used B16 melanoma cells to assess the effects of GA on mushroom tyrosinase (a copper-containing enzyme), tyrosinase inhibitory activity and melanin content. High levels of tyrosinase have been shown to induce melanoma. GA had a strong antityrosinase activity and suppressed murine tyrosinase action and melanin levels. Researchers also determined GA effectively down-regulated generation of reactive species (RS) and enhanced the ratio of reduced glutathione (GSH)/ oxidized glutathione (GSSG).

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