Xanthines Protect Against Wrinkles

TOKYO—Extracts of cacao bean and cola nut containing polyphenols and xanthine derivatives may prevent UV-induced wrinkle formation, according to a new study from Kose Co. Ltd. (Photodermatol Photoimmunol Photomed. 2007 Apr-Jun;23(2-3):86-94). Researchers applied plant extracts containing xanthin derivatives or the xanthine derivatives alone to the dorsal skin of hairless mice; the animals were then exposed to UVA radiation for 15 weeks. Topical application of cacao bean or cola nut extract and caffeine, theobromine and theophylline significantly prevented photodamage including wrinkle formation and histological alterations. The xanthines also reduced total hydroxyproline and pepsin-resistant hydroxyproline content, protecting dermal connective tissue and collagen. In addition, the extracts prevented neutrophil infiltration caused by UVA irradiation.

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