Fight Aging with Pomegranate, Soy and Coffeeberry Ingredients

According to Steifel Labs, which was first to market the extract in May 2007 with its 1 percent Coffeeberry Revale skin line, the coffee cherry extract has an oxygen radical absorbance capacity (ORAC) between 15,000 and 17,500. Thus, it has great free-radical quenching ability and can prevent and neutralize environmental damage and oxidative stress. Not surprisingly, it has been shown to make one’s skin smoother, even skin tone and diminish the appearance of fine lines.

A six week, double blind study was done by Steifel Labs to measure the effects of its coffeeberry. Subjects applied a RevaleSkin facial cleanser twice a day followed by a Revale day cream in the morning, and a Revale night cream in the evening. The 30 subjects, aged 30 to 70, were further broken down with 10 people randomly selected to have a split-face protocol with Revale formulations applied to half of their face and placebo creams applied to the other half. The results showed significant improvement in hyperpigmentation, fine lines and wrinkles, and overall appearance in the skin to which RevaleSkin products were applied. Zoe Draelos, who did a 12-week study of 50 volunteers, found similar results. “During our study, we began to see improvement in skin texture after three weeks of application,” she said.

David McDaniel, M.D., assistant professor of dermatology at the Eastern Virginia Medical School, who tested the RevaleSkin products, also reported: “There are significant benefits of coffeeberry clinically, but also in vitro testing on human skin fibroblast cells for reducing the appearance of aging/photoaging, and for protective benefits for the free radicals and inflammatory response as well as collagen and dermal matrix.”13

Pomegranate, soy and coffeeberry deliver to marketers and consumers two of the biggest trends in the current cosmeceutical marketplace: natural and anti-aging formulations. Look for many more plant and food products to be incorporated into the burgeoning, anti-aging category in the near future. ■

Jeanette Jacknin, M.D., is a board-certified dermatologist and author of the book “Smart Medicine for Your Skin”, originally published by Penguin Putnam and now available at DrJacknin.com.

REFERENCES

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2. De Nigris F et al. “Beneficial effects of pomegranate juice on oxidation-sensitive genes and endothelial nitric oxide synthase activity at sites of perturbed shear stress.” Proc Natl Acad Sci USA. 102, 13:4896-901, 2005, www.pnas.org  

3. Seeram NP et al. “ In vitro antiproliferative, apoptotoic and antioxidant activites of punicalagin, ellagic acid, and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice.” J Nutr Biochem.16, 6:360-7, 2005. www.elsevier.com/locate/nutbio

4. Mehta Re, Lansky EP. “Brest cancer chemopreventive properties of pomegranate ( Punica granatum) fruit extracts in a mouse mammary organ culture.” Eur J Cancer Prev.13, 4:345-8, 2004.

5. Lansky EP el al. “Pomegranate ( Pumica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel.” Invest New Drugs.23, 2:121-2, 2005.

6. Aslam, MN, Lansky EP, et al. “Pomegranate as a cosmeceutical source: pomegranate fractions promote proliferation and procollagen synethsis and inhibit matrix metalloproteinase-1 production in human skin cells, J Ethnopharmacol. 20,103(3): 311-318, 2006.

7. Carl R. Thornberg, “Cosmeceuticals containing herbs: fact, fiction and future,” Dermatol Surg.31(7 Pt 2):873-80, Jul 2005

8. Navindra Seeram, [My paper] “Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States.” J Agric Food Chem.56(4):1415-22, Feb 2008

9. Carl R Thornfeldt, M.D.FAAD, “Chronic inflammation is etiology of extrinsic aging,” J Cos Derm. 7(1), 78-82, March 2008

10. Leslie Baumann, M.D., “Botanical ingredients in cosmeceuticals.” J Drugs Derm. Nov 2007

11. Wei, H,. “Photoprotective action of isoflavone genistein: models, mechanisms, ad relevance to clinical dermatology, “J Am Acad Dermatol. 39(2, pt.1):271-272, 1998.

12. Opt cit. 10

13. Wendy Lewis, “Here’s what’s new in advanced skin care products,” Cosmeceuticals Roundup. Sept. 2007. www.psp-interactive.com/issues/articles/2007-2009

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