Sederma ~ VOLULIP™

The demand for plumper lips is a growing phenomenon as women, who have naturally fine lips, wish to give them more sensuality. Furthermore with age, women try to retrieve attractive lips, which have lost their contour and definition because of dryness, loss in volume and ptosis and decrease in derma density.

Sederma, Le Perray en Yvelines Ccedex, France, developed VOLULIP™, an active substance containing a plant Portulaca “Kiss-mequick” extract, associated with a natural modified matrikine-mimetic peptide, whose main activity is to stimulate hyaluronic acid synthesis. In order to demonstrate the product efficacy and its mechanism of action, several in vitro tests have been carried out following three axes, stimulation of dermal matrix molecules (collagen 1, collagen 3, fibronectin, HSP47), reinforcement of DEJ molecules (collagen 4, laminin 5), improvement of hydric sphere (hyaluronic acid, aquaporin 3).

Sederma also carried out two clinical studies to prove VOLULIP efficacy on youth, hydration and lip volume. The first one involved 29 panelists with a twice daily application of a balm containing 1 percent VOLULIP for a month. It associated several complementary methods such as Aeroflexmeter® (device developed and patented by Sederma, which allows to characterise skin mechanical properties without any contact, thanks to a compressed air jet), fringe projections (FOITS) and MoistureMeter-D.

The second one was carried out on a total of 21 panelists to measure re-densification with an ultrasonor echograph. The results are very significant. Researchers observed a gain of +13.3 percent of firmness, +50.6 percent of hydration, +10.5 percent of softness, +15.1 percent of volume, +9.2 percent of curvature (radius of curvature of the lower lip) and an increase of +19.6 percent of the surface of the central area of the lower lip for volunteers with very fine lips.

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