Study Supports Matrixyl™ Anti-Wrinkle Effects

EDISON, N.J.—Sederma Inc. announced two recent company studies support claims about the anti-wrinkle effect of the non-irritating peptide Matrixyl™. In the first study, 16 volunteers applied a cream with 3 percent Matrixyl or a cream with 0.07 percent retinol. Study subjects applied the cream daily for two months and then twice daily for two months. Both treatments showed similar results in reducing wrinkle depth, wrinkle surface and wrinkle length. Skin thickness increased by 6.5 percent after two months and 8.6 percent after four months with Matrixyl; retinol increased skin thickness by 4.0 percent after two months and 8.7 percent after four months.

The second study included two groups of 30 volunteers, who used a 5 percent Matrixyl cream or a placebo cream twice daily on face and décolleté for four months. A 13-percent net decrease in roughness was obtained with Matrixyl after four months, compared to no change with placebo. In addition, after four months, Matrixyl had a 27-percent improvement in wrinkle mean depth and 36-percent improvement in wrinkle volume.

According to Sederma (Sederma.fr), Matrixyl stimulates fibroblasts to synthesize collagen I, collagen IV, fibronectin and glycosaminoglycans, restoring the matrix and epidermal-dermal junction to reduce wrinkles.

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