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Bathroom Talk: Microencapsulation for Mouthwash Solutions


PARIS and GOTHENBURG, Sweden— According to a French study, the development of new technologies such as microencapsulation (like the GingiNat concept) may allow an in situ slow release of active ingredients during several hours, and open new perspectives for mouthwash solutions (Rev Stomatol Chir Maxillofac. 2010; 111(3):148-51).Currently, mouthwash solutions, which are mainly used for their antiseptic properties, include synthetic agents (chlorhexidine, triclosan, etc.) or essential oils (especially Listerine); but many natural extracts may also be used that are associated with antiseptic effects and direct action on host response due to their antioxidant, immunoregulatory, analgesic, buffering or healing properties such as: avocado oil, manuka oil, propolis oil, grapefruit seed extract, Pycnogenol, aloe vera, coenzyme Q10 (CoQ10), green tea and megamin.

In a 2010 Swedish study, researchers found GingiNat mouthwash solution at 6 percent had a significant efficiency on plaque, gingivitis and halitosis after 21 days of use, making it a good complementary treatment for gingivitis (Rev Stomatol Chir Maxillofac. 2010;111(3):144-7).

Researchers at the University of Gothenburg assessed the efficiency of a mouthwash containing microencapsulated natural extracts (GingiNat, LoB5 Foundation, Paris) on gingivitis. A total of 20 volunteers aged 35 to 39 with significant gingivitis (bleeding when tooth-brushing) used a 6-percent GingiNat mouthwash solution, two to three times per day (according to oral hygiene habits) for 21 days in addition to their usual oral care. Each volunteer was examined at day zero, four, seven and 21. The Löe and Silness Plaque Index, the Russel Periodontal Index, a breath index (halitosis) and oral tissue tolerance were assessed. Finally, each volunteer filled in a daily follow-up form and answered a questionnaire on tolerance and acceptability.

A significant decrease of the dental plaque index was observed on day four, seven and 21, in respectively 29, 48 and 71 percent of volunteers. This decrease reached 18 percent on day four (P=0.014), 32 percent on day seven (P=0.002) and 47 percent on day 21 (P<0.001). A significant decrease of the periodental index was observed on day four, seven and 21, in respectively 52, 81 and 95 percent of volunteers. This decrease reached 30 percent (P=0.001) on day four, 49 percent (P<0.001) on day seven and 78 percent (P<0.001) on day 21. A significant improvement of the breath index was noted on day four, seven and 21, in respectively 43, 52 and 48 percent of volunteers. This improvement reached 29 percent (P=0.004) on day four, 35 percent (P=0.001) on day seven and 32 percent (P=0.002) on day 21. The mouthwash was well tolerated. The patients liked its effectiveness and organoleptic properties. All patients expressed the wish to continue using this solution.

The researchers said tolerance and acceptability were good despite the long and repeated use. Further studies are needed to have a detailed analysis of its efficiency in the long run and on patients presenting with various forms of periodontitis.

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