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Nut Oil Fatty Acids Regenerate Skin

November 1, 2010 Comments
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NEW BRUNSWICK, N.J.—According to a study published in The Journal of Cosmetic Dermatology, natural fatty acids from Pouteria lucuma nut promoted skin regeneration and, thus, may have applications in medicine and skin care (2010;9(3)185-95). Cell migration, angiogenesis, inflammation and extracellular matrix remodeling are key events in wound healing. Natural products, including fatty acids (FAs), can accelerate wound healing by modulating the aforementioned events. GC–MS analysis of FAs methyl esters (FAMES) was used for chemical characterization of lucuma nut oil (LNO). In vitro studies were carried out with LNO investigating the induction of cell migration, cytoskeleton remodeling of human fibroblasts, inhibition of LPS-induced nitric oxide production in macrophages, and antibacterial and antifungal effects. Two in vivo studies were carried out to study LNO’s effect on angiogenesis and wound healing: (1) tail fin regeneration in transgenic zebrafish larvae expressing enhanced green fluorescent protein (EGFP) in vascular endothelial cells was used to study vessel sprouting and wound healing and (2) the closure of wounds was evaluated in CD-1 mice after topical applications of LNO-containing formulations.

Lucuma nut oil is a mixture of FAs, 99.7 percent of which were characterized. Major components of LNO (w/w) are linoleic acid (38.9 percent), oleic acid (27.9 percent), palmitic acid (18.6 percent), stearic acid (8.9 percent), and gamma-linolenic acid (2.9 percent). In vitro studies showed LNO significantly promoted migration and vinculin expression in human fibroblasts. LNO decreased LPS-induced nitric oxide production and did not display significant antibacterial or antifungal effects. LNO induced tail fin regeneration in transgenic zebrafish larvae 48 hours after tail fin amputation and significantly accelerated cutaneous wound closure in CD-1 mice.

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