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Astaxanthin Lessens UV-Induced Wrinkles, Sagging

August 12, 2010 Comments
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TOCHIGI, Japan—Astaxanthin may have a significant benefit on protecting against UVA-induced skin photoaging such as sagging and wrinkles, according to a recent study published in the  Journal of Dermatological Science  (July 12, 2010). Exposing the skin repetitively to UVA radiation causes sagging more frequently than wrinkling, which is mainly attributed to its biochemical mechanism to upregulate the expression of matrix-metalloproteinase (MMP)-1 and skin fibroblast elastase (SFE)/neutral endopeptidase (NEP), respectively. Korean researchers examined the effects of astaxanthin on the induction of MMP-1 and SFE by UVA treatment of cultured human dermal fibroblasts.

UVA radiation elicited a significant increase in the gene expression of MMP-1 as well as SFE/NEP (to a lesser extent), which was followed by distinct increases in their protein and enzymatic activity levels. The addition of astaxanthin at concentrations of 4 micron to 8 micron immediately after UVA exposure significantly attenuated the induction of MMP-1 and SFE/NEP expression elicited by UVA at the gene, protein and activity levels although both the UVA stimulation and the subsequent astaxanthin inhibition were greater for MMP-1 than for SFE/NEP. Analysis of the UVA-induced release of cytokines revealed UVA significantly stimulated only the secretion of IL-6 among the cytokines tested and astaxanthin significantly diminished only the IL-6 secretion. Based on different effective concentrations of astaxanthin, a major mode of action leading to the inhibition elicited by astaxanthin depends on inhibition of UVA effects of the reactive oxygen species-directed signaling cascade, but not on interruption of the IL-6-mediated signaling cascade.

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