LE PERRAY, France—According to a new test by France-based Sederma SAS, Matrixyl® 3000, the matrikine-based anti-aging ingredient, may help repair the UV damage-prone papillary dermis. The papillary dermis, located just under the dermis/epidermis junction (DEJ), is more fragile than the reticular dermis and is intensely affected by photoaging. Papillary fibroblasts are fundamental to promote epidermal morphogenesis and wound healing, which is why papillary dermis repair delivers visible anti-wrinkle benefits.
In vivo studies have shown the positive matrix reinforcing effect of Matrixyl 3000 by measuring the subepidermal low echogenic band (SLEB) density that corresponds to the papillary dermis. After one month, a significant improvement, corresponding to a gain in age of 1.8 years, was seen, and confirmed after two months. Therefore, the photo-induced aging is then delayed by 5.5 years.
Another analysis of the papillary dermis by confocal laser microscopy showed Matrixyl 3000 helps reduce the fiber fragmentation and notably supports the reconstruction of the papillary dermal fiber network.
