HOLZMINDEN, Germany—Symrise launched SymSitive™ 1609, an active ingredient for treating sensitive skin and dermal irritations. Increased permeability of the stratum corneum (the upper layer of the skin) and hyper reactivity of the peripheral nervous system both heighten the skin’s response to external factors. SymSitive 1609 acts as a sensitivity regulator by increasing the skin’s tolerance threshold. The substance has a major impact on burning and stinging, as demonstrated in a clinical study of 20 subjects, according to the company. Capsaicin-induced stinging and burning was lowered below the sensory threshold immediately after using SymSitive 1609.