One 2005 study sought to determine whether a defined biomimetic mixture of components of Evodia fruit extract could inhibit inflammation in human cells and skin. Both once and twice daily applications of a 0.1 to 1 percent Evodia biomimetic mixture for two weeks significantly inhibited erythema in the skin after irradiation with UVB. These effects were attributed to the quinazoline alkaloid’s rutaecarpine (which has been shown to have in vivo anti-inflammatory activity), evodiamine, dehydroevodiamine, and the triterpenoid evodin. The results also suggest the components of the Evodia biomimetic mixture are most likely working synergistically. DERMAdoctor’s Aint Misbehavin Medicated Emergency Acne Spot Treatment has already discovered Evodia’s potential in healing the skin. These recently rediscovered ingredients can potentially play an effective role in optimal skin care solutions. Sea buckthorn seed oil, unique for its omega-7 content, is fantastic for making hair and skin luxurious and shiny and for the treatment of burns and eczema. Rooibos tea, the only natural source of the anti-allergenic aspalathin, is a naturally valuable treatment for sensitive dry skin in newborns and the elderly. And, Evodia, with its anti-inflammatory quinazoline alkaloids, significantly inhibits erythema in the skin after irradiation with UVB, and is also useful as an astringent in the treatment of acne. With their time-tested usefulness in Asia and South Africa, sea buckthorn, roobios and Evodia are a valuable addition to today’s cosmeceuticals and will be increasingly used in the years to come.
Jeanette Jacknin, M.D., is a board-certified dermatologist and author of the book “Smart Medicine for Your Skin,” originally published by Penguin Putnam and now available at www.DrJacknin.com
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